Dose-dependent Relationships of Same-day and Typical Substance Use to Sleep Duration in College Cannabis and Alcohol Users: A Multilevel Modeling Approach Using Daily Diary Data

This study characterized how quantities of cannabis and alcohol use affect sleep. Single-day typical patterns were considered to assess acute-chronic interactions. Linear non-linear associations assessed dose-dependence. College students (n=337; 52% female) provided 11,417 days data, with up five time points per day. Daily self-reported sleep duration, quantity, quantity subjected linear mixed modeling capture curvilinear between single-day on same-night Sleep duration (difference bedtime waketime) was the outcome. Quantity used each day andtypical across all predictors in models. Parallel variables Follow-up analyses excluded alcohol-cannabis co-use. Main effects observed when cannabis-use modeled. Higher than doses associated longer durations, but only a point; at highest doses, shortened A main effect two interactions (single-day both use) alcohol-use Greater consumption given led shorter sleep, typically heavier drinkers required higher lighter experience these adverse effects. models suggested co-use may contribute purported sleep-promoting cannabis.